Key result
Rapid MLC-2s dephosphorylation correlates with reduced maximal shortening during rat slow twitch muscle fatigue.
Population
Rat soleus muscles with maintained blood supply in situ at 37°C
Design
Preclinical
Follow-up
15 min
Authors
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May distinguish fatigue mechanisms in shortening vs isometric contractions; leaves open translation beyond rat soleus models.
p-value: p=<0.05
In rat slow twitch skeletal muscle, fatigue during shortening contractions occurs in three distinct phases, with MLC-2s dephosphorylation playing a key role in reduced muscle shortening.
Hortemo et al. (2013) studied Muscle fatigue (n=115). In situ shortening contractions vs. Initial values / contralateral resting muscle was evaluated on Maximal shortening (Smax) and MLC-2s phosphorylation (p=<0.05). During shortening contractions in rat slow twitch skeletal muscle, fatigue developed in three distinct phases, with rapid dephosphorylation of Myosin Light Chain-2 (MLC-2s) correlating with reduced maximal shortening.
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