Key result
In rats with chronic heart failure, slow twitch skeletal muscle demonstrated attenuated fatigue and a significantly less pronounced increase in baseline tension during isotonic exercise compared to sham-operated controls.
Why the study?
Does chronic heart failure alter skeletal muscle fatigue during isotonic contractions in rats?
Population
Rats with chronic heart failure 6 weeks following coronary artery ligation, classified as failing if left…
Comparison
Isotonic contractions of slow twitch soleus… vs Sham-operated rats
Design
Preclinical
Follow-up
6 weeks post-ligation
Authors
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May indicate compensatory skeletal muscle changes in heart failure; leaves open translation to human exercise tolerance.
Does chronic heart failure alter skeletal muscle fatigue during isotonic contractions in rats?
Absolute Event Rate: 18% vs 26%
p-value: p=<0.001
Contrary to previous studies using isometric contractions, slow twitch skeletal muscle fatigue during isotonic contractions is not exacerbated in rats with chronic heart failure.
Munkvik et al. (2011) studied Chronic heart failure (n=98). Coronary artery ligation (Chronic heart failure model) vs. Sham operation was evaluated on Baseline tension (Tbl) at 100 seconds of isotonic stimulation (% of afterload) (p=<0.001). In rats with chronic heart failure, slow twitch skeletal muscle demonstrated attenuated fatigue and a significantly less pronounced increase in baseline tension during isotonic exercise compared to sham-operated controls.
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