Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 21, 2011Journal of Cellular and Molecular MedicineOpen Access

IGF‐1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: role of microRNA‐1 and microRNA‐133a

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does IGF-1 deficiency prevent abdominal aortic constriction-induced cardiac hypertrophy and contractile dysfunction in mice?

Population

Liver-specific IGF-1-deficient (LID) mice and C57/BL6 mice, and neonatal rat cardiomyocytes (NRCMs).

Comparison

IGF-1 deficiency subjected to abdominal aortic… vs Wild-type C57/BL6 mice subjected to AAC or sham…

Design

Preclinical

Follow-up

4 weeks

Authors

YHYinan HuaTufts Medical CenterYZYingmei ZhangBGI Group (China)JRJun RenGeneral Cardiology

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for IGF-1 modulation in pressure-overload models; leaves open translation to human cardiac disease.

Structured PICO

Does IGF-1 deficiency prevent abdominal aortic constriction-induced cardiac hypertrophy and contractile dysfunction in mice?

P
Population
Liver-specific IGF-1-deficient (LID) mice and C57/BL6 mice, and neonatal rat cardiomyocytes (NRCMs).
I
Intervention
IGF-1 deficiency (LID mice) subjected to abdominal aortic constriction (AAC) for 4 weeks; in vitro transfection of miR-1 and miR-133a prior to IGF-1 exposure.
C
Comparator
Wild-type C57/BL6 mice subjected to AAC or sham surgery; NRCMs transfected with negative control miRNA.
O
Outcome
Cardiac geometric and functional changes (ventricular wall thickness, LVEDD, LVESD, cardiomyocyte shortening capacity) and myocardial morphology at 4 weeks.surrogate

IGF-1 deficiency retards pressure overload-induced cardiac hypertrophy and contractile changes by alleviating the down-regulation of miR-1 and miR-133a.

Cite This Study

Hua et al. (2011) studied this question.

synapsesocial.com/papers/6a199955443d3ecd7cdecbcehttps://doi.org/10.1111/j.1582-4934.2011.01307.x

Topics

Heart failureHFrEF treatmentEchocardiography
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA2007 · 1,666 citations
  2. 2Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling2000 · 388 citations
  3. 3The Cardiac-specific Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Induces Hypertrophy and Dilated Cardiomyopathy Associated with Increased Protein Phosphatase 2A Activity2002 · 244 citations
  4. 4Myocardin Induces Cardiomyocyte Hypertrophy2006 · 144 citations
  5. 5Gβγ-dependent Phosphoinositide 3-Kinase Activation in Hearts with in Vivo Pressure Overload Hypertrophy2000 · 205 citations