What question did this study set out to answer?

To evaluate the impact of obesity and body fat distribution on splanchnic insulin metabolism and their relationship to peripheral insulin sensitivity.

December 1, 1986Journal of Clinical InvestigationOpen Access

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

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To evaluate the impact of obesity and body fat distribution on splanchnic insulin metabolism and their relationship to peripheral insulin sensitivity.
Evaluated splanchnic insulin kinetics and peripheral insulin sensitivity in 6 nonobese and 16 obese premenopausal women (N=22).
Measured prehepatic insulin secretion, portal vein insulin concentrations basally and following glucose stimulation, hepatic extraction fraction, and waist-to-hip girth ratio (WHR).
Obese women had significantly higher basal and glucose-stimulated prehepatic insulin production and portal vein insulin levels than nonobese women, which correlated with adiposity rather than WHR.
Higher WHR correlated inversely with the hepatic insulin extraction fraction and directly with posthepatic insulin delivery and peripheral insulinemia.
The impairment in hepatic insulin extraction seen with elevated WHR correlated directly with reduced peripheral insulin sensitivity.

Authors

APAlan N. PeirisTexas Tech University RMRobert A. MuellerDartmouth College GSGeorge A. SmithMarquette University

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Implication

Observational study reveals altered splanchnic insulin extraction drives hyperinsulinemia in upper-body obesity, indicating a direct link to reduced peripheral insulin sensitivity.

Cite This Study

Peiris et al. (1986) studied this question.

synapsesocial.com/papers/6a199d17196cd56b09ea7995 https://doi.org/10.1172/jci112758

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Implication

Observational study reveals altered splanchnic insulin extraction drives hyperinsulinemia in upper-body obesity, indicating a direct link to reduced peripheral insulin sensitivity.

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

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Discussion

Implication

Cite This Study

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

Key Points

Discussion

Implication

Cite This Study

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