What does this research mean for the field?

A novel picornavirus species, tentatively named Human Cosavirus E1 (HCoSV-E1), is present in the stool of a child with acute diarrhea and belongs to the newly proposed Cosavirus genus. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 2008Virology JournalOpen Access

Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea

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Population

A stool sample from a child with acute diarrhea collected in Melbourne, Australia, plus a screening cohort…

Design

Other

Authors

LHLori R. HoltzWashington University in St. Louis SFStacy R. FinkbeinerTeva Pharmaceuticals (United States)CKCarl D. KirkwoodCenters for Disease Control and Prevention

Discussion

Member takes

Implication

No immediate clinical implications for pediatric diarrhea; leaves open HCoSV-E1 prevalence and pathogenicity for further study.

Structured PICO

Population

A stool sample from a child with acute diarrhea collected in Melbourne, Australia, plus a screening cohort of 253 pediatric stool specimens from St. Louis, USA and 143 from Melbourne, Australia.

Intervention

Metagenomic mass sequencing, RT-PCR, and RACE

Outcome

Identification and genomic sequencing of a novel virus

Identification of Human Cosavirus E1 highlights the undiscovered microbial diversity of the human gut virome, though its pathogenic role in acute diarrhea remains unknown.

Limitations

Unable to obtain additional sequence at the 5' end due to RNA secondary structures
Relationship of HCoSV-E1 to diarrhea or other human diseases remains unknown

Cite This Study

Holtz et al. (2008) studied this question.

synapsesocial.com/papers/6a19b2983f3ec013f0def079 https://doi.org/10.1186/1743-422x-5-159

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December 1, 2008Virology JournalOpen Access

Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea

View Full Paper

Ask AI

Bookmark

Population

A stool sample from a child with acute diarrhea collected in Melbourne, Australia, plus a screening cohort…

Design

Other

Authors

LHLori R. HoltzWashington University in St. Louis SFStacy R. FinkbeinerTeva Pharmaceuticals (United States)CKCarl D. KirkwoodCenters for Disease Control and Prevention

Discussion

Member takes

Implication

No immediate clinical implications for pediatric diarrhea; leaves open HCoSV-E1 prevalence and pathogenicity for further study.

Structured PICO

Population

A stool sample from a child with acute diarrhea collected in Melbourne, Australia, plus a screening cohort of 253 pediatric stool specimens from St. Louis, USA and 143 from Melbourne, Australia.

Intervention

Metagenomic mass sequencing, RT-PCR, and RACE

Outcome

Identification and genomic sequencing of a novel virus

Identification of Human Cosavirus E1 highlights the undiscovered microbial diversity of the human gut virome, though its pathogenic role in acute diarrhea remains unknown.

Limitations

Unable to obtain additional sequence at the 5' end due to RNA secondary structures
Relationship of HCoSV-E1 to diarrhea or other human diseases remains unknown

Cite This Study

Holtz et al. (2008) studied this question.

synapsesocial.com/papers/6a19b2983f3ec013f0def079 https://doi.org/10.1186/1743-422x-5-159

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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