Key result
Genetic analysis of human cosaviruses identified a new candidate species (HCoSV-F), a recombinant genome between species D and E, and 26 new genotypes, highlighting extensive viral diversity.
Observational (n=761)
Yes
The study expands the known genetic diversity of human cosaviruses, identifying a new species, evidence of recombination, and 26 new genotypes, highlighting their high diversity similar to human enteroviruses.
No immediate clinical implications; extends known cosavirus diversity for future surveillance and pathogenicity studies.
The proposed viral genus human Cosavirus (HCoSV) consists of diverse picornaviruses found at high prevalence in the feces of children from developing countries. We sequenced four near-full length genomes and 45 partial VP1 region from HCoSV in human feces from healthy children and children with acute flaccid paralysis in Pakistan, Nigeria and Tunisia and from healthy and diarrhetic adults in Nepal. Genetic analyses of the near-full length genomes revealed presence of a new candidate cosavirus species provisionally labelled as species F (HCoSV-F). A HCoSV genome showed evidence of recombination between species D and E viruses at the P1/P2 junction indicating that these viruses may be reclassified as a single highly diverse species. Based on genetic distance criteria for assigning genotypes corresponding to neutralization serotypes in enteroviruses we identified 26 new HCoSV genotypes belonging to species A, D, and E. The detection of a large number of HCoSV genotypes based on still limited geographic sampling indicates that the phenotypic effects of cosaviruses on infected subjects are likely to be as highly diverse as those of human enteroviruses.
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Kapusinszky et al. (2012) conducted an observational in Cosavirus infection (n=761). Cosavirus vs. Uninfected individuals / Healthy controls was evaluated on Identification of new cosavirus species, recombination events, and genotypes. Genetic analysis of human cosaviruses identified a new candidate species (HCoSV-F), a recombinant genome between species D and E, and 26 new genotypes, highlighting extensive viral diversity.
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