Key result
Among 2,459 pediatric patients with acute gastroenteritis, SAFV and HCoSV were detected in 0.9% and 1.6% of stool samples, respectively, with HCoSV-C comprising 97% of HCoSV cases.
Why the study?
Saffold virus and human cosavirus are emerging picornaviruses linked to gastrointestinal and other clinical infections, warranting characterization of their prevalence and genotypes.
Cross-Sectional (n=2,459)
Yes
The study demonstrates a low prevalence of SAFV and HCoSV in pediatric patients with acute gastroenteritis in Thailand, with a notable increase in the HCoSV-C genotype compared to previous reports.
Low prevalence suggests no change to testing in pediatric gastroenteritis; leaves open questions on HCoSV-C emergence in Thailand.
Saffold virus (SAFV) and human cosavirus (HCoSV) are emerging viruses of the Picornaviridae family. They have been shown to associate with gastrointestinal infection and more recently these viruses have also been demonstrated to associate with other clinical infections such as the respiratory tract, cardiovascular system, and the cerebral ventricular system. In this study, 2459 stool specimens collected from pediatric patients admitted to hospitals with acute gastroenteritis from January 2017 to December 2022, were screened for SAFV and HCoSV utilizing reverse transcription-polymerase chain reaction. Positive samples were then characterized into genotypes via nucleotide sequencing and bioinformatic analysis. Of the 2459 samples, 21 and 39 were positive for SAFV (0.9%) and HCoSV (1.6%), respectively. Three genotypes of SAFV were identified-SAFV-1 (38%), SAFV-2 (24%), and SAFV-3 (38%). Two genetic groups of HCoSV were identified-HCoSV-C (97%) and HCoSV-A (3%), demonstrating a large increase of HCoSV-C as compared to those reported previously from the same geographical region in Thailand. This study provides the prevalence of SAFV and HCoSV genotypes in Chiang Mai, Thailand during a period of 6 years from 2017 to 2022.
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Hogben et al. (2023) conducted a cross-sectional in Acute gastroenteritis (n=2,459). Saffold virus (SAFV) and human cosavirus (HCoSV) was evaluated on Prevalence and genotypes of SAFV and HCoSV. Among 2,459 pediatric patients with acute gastroenteritis, SAFV and HCoSV were detected in 0.9% and 1.6% of stool samples, respectively, with HCoSV-C comprising 97% of HCoSV cases.
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