Key result
Saffold virus was detected in 1.5% (9/608) of fecal specimens from children with diarrhea in Thailand, with four genotypes identified.
Cross-Sectional (n=608)
Saffold virus is present at a low prevalence (1.5%) in pediatric patients with diarrhea in Thailand, with multiple circulating genotypes.
Saffold virus detection does not warrant changes in pediatric diarrhea management; leaves open its etiologic role pending prospective studies.
Saffold virus (SAFV) is a newly discovered human virus which is classified into the genus Cardiovirus of the family Picornaviridae. A total of 608 fecal specimens collected during January 2012 to December 2013 from children with diarrhea in Chiang Mai, Thailand were investigated for SAFV by RT-nested PCR and sequence analysis. Of these, nine out of 608 (1.5%) were positive for SAFVs and four genotypes were identified, SAFV1, SAFV2, SAFV3, and SAFV4. SAFV mono-infection was found in five cases (CMH-S038-12, CMH-S071-12, CMH-S102-12, CMH-N029-12, and CMH-S048-13), while co-infection with other viruses causing diarrhea was observed in four cases (CMH-S021-12, CMH-S115-12, CMH-N048-13 and CMH-N103-13). This study provides more information about the genetic background of SAFV circulating in pediatric patients with diarrhea in Thailand.
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Yodmeeklin et al. (2015) conducted a cross-sectional in Diarrhea (n=608). Saffold virus (SAFV) infection was evaluated on SAFV positivity. Saffold virus was detected in 1.5% (9/608) of fecal specimens from children with diarrhea in Thailand, with four genotypes identified.
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