What does this research mean for the field?

The higher incidence of stroke among Japanese men in Japan compared to those in Hawaii is primarily driven by small intracerebral artery pathology rather than large artery atherosclerosis, with hypertension acting as a key causal factor. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

January 1, 1994Hypertension ResearchOpen Access

Is Hypertension Related Intra- and Extracerebral Artery Disease Responsible for the Difference in Stroke Incidence among Japanese Men in Japan and Hawaii?

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Population

407 men of Japanese ancestry, comprising 232 men in Japan and 175 men in Hawaii, evaluated via histologic…

Design

Cross-sectional

Authors

DRDwayne ReedFort Ross Conservancy

Discussion

Member takes

Implication

Hypertension and Asian diet may drive excess small vessel pathology and lacunar infarcts in Japan; supports small artery disease over atherosclerosis as explanation for geographic stroke differences.

Structured PICO

Population

407 men of Japanese ancestry, comprising 232 men in Japan and 175 men in Hawaii, evaluated via histologic sections of basal ganglia.

Outcome

Prevalence of different measures of small artery pathology and lacunar infarcts in histologic sections of basal gangliasurrogate

The higher stroke incidence in Japanese men in Japan compared to Hawaii is likely driven by small intracerebral artery pathology related to hypertension and diet, rather than large vessel atherosclerosis.

Cite This Study

Dwayne Reed (1994) studied this question.

synapsesocial.com/papers/6a19b34c60e90a7f5fea90c8 https://doi.org/10.1291/hypres.17.supplementi_s37

Topics

Hypertension management

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Implication

Hypertension and Asian diet may drive excess small vessel pathology and lacunar infarcts in Japan; supports small artery disease over atherosclerosis as explanation for geographic stroke differences.

Is Hypertension Related Intra- and Extracerebral Artery Disease Responsible for the Difference in Stroke Incidence among Japanese Men in Japan and Hawaii?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Is Hypertension Related Intra- and Extracerebral Artery Disease Responsible for the Difference in Stroke Incidence among Japanese Men in Japan and Hawaii?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider