Key result
This review summarizes current network models, sex differences, and translational implications regarding the role of carotid bodies in the integrated cardiorespiratory response to hypoxia.
This review summarizes current knowledge on the brain mechanisms and carotid body involvement in the cardiorespiratory response to hypoxia, with implications for treating sleep apnea-related hypertension and heart failure.
Advances in our understanding of brain mechanisms for the hypoxic ventilatory response, coordinated changes in blood pressure, and the long-term consequences of chronic intermittent hypoxia as in sleep apnea, such as hypertension and heart failure, are giving impetus to the search for therapies to "erase" dysfunctional memories distributed in the carotid bodies and central nervous system. We review current network models, open questions, sex differences, and implications for translational research.
No takes yet. Share an insight, caveat, or question.
Lindsey et al. (2018) conducted a review in Hypoxia, sleep apnea, hypertension, and heart failure. This review summarizes current network models, sex differences, and translational implications regarding the role of carotid bodies in the integrated cardiorespiratory response to hypoxia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: