Key result
Radiotherapy for cancer is associated with a high probability of delayed cardiovascular complications occurring 3 to 30 years after treatment, as highlighted by a case of early coronary artery disease.
Why the study?
Cardiovascular complications of radiotherapy are common and may occur 3 to 30 years after treatment, affecting long-term prognosis.
What are the cardiovascular complications, long-term risks, and screening algorithms for patients who undergo radiotherapy?
What are the cardiovascular complications, long-term risks, and screening algorithms for patients who undergo radiotherapy?
Radiotherapy is associated with significant long-term cardiovascular risks, necessitating awareness and appropriate screening for cardiotoxicity up to 30 years post-treatment.
Highlights need for prolonged CV vigilance after radiotherapy; leaves open standardized screening algorithms.
Radiotherapy is an integral part of the cancer treatment, including with mediastinum, breast cancer. In this case, cardiovascular complications of the treatment are quite common. The long-term prognosis can be determined not only by the effectiveness of radiotherapy, but also by cardiovascular risks. A feature of cardiotoxicity of radiation therapy is the high probability of its occurrence in the delayed period of 3–30 years after treatment. The article highlights the results of published epidemiological studies of cardiotoxicity of radiotherapy, as well as the available screening algorithms for cardiovascular complications in patients who underwent radiotherapy. Own clinical observation of the early debut of coronary artery disease after combined chemoradiotherapy of diffuse large B-cell non-Hodgkin lymphoma is presented.
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Shavarova et al. (2020) conducted a review in Cancer undergoing radiotherapy. Radiotherapy was evaluated on Cardiovascular complications (cardiotoxicity). Radiotherapy for cancer is associated with a high probability of delayed cardiovascular complications occurring 3 to 30 years after treatment, as highlighted by a case of early coronary artery disease.
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