October 14, 2010Journal of Veterinary Pharmacology and TherapeuticsOpen Access

Lack of efficacy of low‐dose spironolactone as adjunct treatment to conventional congestive heart failure treatment in dogs

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Why the study?

Does low-dose spironolactone improve survival in dogs with advanced congestive heart failure?

Population

18 client-owned dogs with advanced congestive heart failure due to either degenerative valve disease or…

Comparison

Spironolactone at a median dose of 0.52 mg/kg… vs Placebo added to conventional heart failure…

Design

Preclinical, randomized, double-blinded, placebo-controlled

Follow-up

6 months

Authors

SSSimone SchüllerUniversity of Bern NINicole IsraëlBarco (Belgium)SVSophie VanbelleUppsala University Hospital

Discussion

Member takes

Implication

Does not support adding low-dose spironolactone for survival in canine advanced CHF; leaves open need for confirmatory veterinary trials.

Structured PICO

Does low-dose spironolactone improve survival in dogs with advanced congestive heart failure?

Population

18 client-owned dogs with advanced congestive heart failure due to either degenerative valve disease (n=11) or dilated cardiomyopathy (n=7)

Intervention

Spironolactone at a median dose of 0.52 mg/kg (range 0.49-0.8 mg/kg) once daily added to conventional heart failure treatment (furosemide, angiotensin-converting enzyme inhibitors, pimobendan and digoxin) for 6 months

Comparator

Placebo added to conventional heart failure treatment (furosemide, angiotensin-converting enzyme inhibitors, pimobendan and digoxin)

Outcome

Survival timeshard clinical

Low-dose spironolactone added to conventional heart failure treatment did not significantly improve survival in dogs with advanced congestive heart failure.

Cite This Study

Schüller et al. (2010) studied this question.

synapsesocial.com/papers/6a1a20cd8db9fef88db4f4fe https://doi.org/10.1111/j.1365-2885.2010.01235.x

Topics

Heart failure HFrEF treatment HFpEF management

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Lack of efficacy of low‐dose spironolactone as adjunct treatment to conventional congestive heart failure treatment in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Lack of efficacy of low‐dose spironolactone as adjunct treatment to conventional congestive heart failure treatment in dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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