Why the study?
Does spironolactone reverse the renal effects of aldosterone in a dog model of hyperaldosteronism?
Population
15 Beagle dogs in a hyperaldosteronism model
Comparison
Spironolactone oral administration vs Aldosterone alone and negative control
Design
Preclinical, 5 x 5 Latin square crossover design
Follow-up
Five periods with a 7-day washout between each period
Authors
Loading...
Provides dose-response data in a dog model; leaves open translation to clinical veterinary or human use.
Does spironolactone reverse the renal effects of aldosterone in a dog model of hyperaldosteronism?
A spironolactone dose of 2 mg/kg once daily completely reverses the renal effects of aldosterone in a dog model, supporting its use for congestive heart failure management in dogs.
Guyonnet et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: