What question did this study set out to answer?

To determine the optimal timing for thermodilution cardiac output measurements in relation to the respiratory cycle.

April 19, 1985JAMA

Thermodilution Cardiac Output Measurement

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Randomized trial assessed cardiac output timing in critically ill patients, suggesting best practices for minimizing variability.

To determine the optimal timing for thermodilution cardiac output measurements in relation to the respiratory cycle.
Prospective study with 32 patients comparing thermodilution measurements at peak-inspiration, end-exhalation, or randomized intervals.
Randomized scheme in both spontaneously breathing and mechanically ventilated patients.
Saline injections at peak-inspiration or end-exhalation showed smaller standard deviations compared to random timings.
Measurements taken at random times resulted in significantly greater variability, recommending avoidance of this practice.

John H. Stevens (1985) studied this question.

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