Key result
10 ml injectate minimizes thermodilution CO variability, whereas 3 ml room temperature differs by ~1.5 L/min.
Why the study?
The accuracy and variability of thermodilution cardiac output measurements using different injectate volumes and temperatures in critically ill patients were not well characterized.
Does injectate volume and temperature affect the accuracy and variability of thermodilution cardiac output determination in critically ill patients?
Population
Critically ill patients requiring intermittent mandatory ventilation
Comparison
Six combinations of injectate volume (10, 5, 3 ml) and temperature (0 degree C and room temperature)
Design
Prospective observational study
Authors
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3 ml room-temperature injectate was associated with greater thermodilution CO variability; leaves open optimal parameters pending randomized trials.
Observational
Does injectate volume and temperature affect the accuracy and variability of thermodilution cardiac output determination in critically ill patients?
For thermodilution cardiac output determination in critically ill patients, 10 ml injectate volumes at 0 degree C or room temperature provide the most reproducible measurements, while 3 ml volumes should be avoided due to high variability.
Pearl et al. (1986) conducted an observational in Critically ill requiring intermittent mandatory ventilation. Injectate volume (10, 5, and 3 ml) and temperature (0°C and room temperature) vs. 10 ml 0°C (reference) was evaluated on Accuracy and variability of cardiac output estimation. Thermodilution cardiac output determination using 10 ml injectate produced the least variability, whereas 3 ml at room temperature resulted in an average absolute difference of 1.51 L/min vs 10 ml 0°C.
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