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June 8, 2004Arteriosclerosis Thrombosis and Vascular Biology

Rat Aortic MCP-1 and Its Receptor CCR2 Increase With Age and Alter Vascular Smooth Muscle Cell Function

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Population

Old versus young F344xBN rat aortas in vivo and isolated early-passage vascular smooth muscle cells

Comparison

MCP-1 treatment and CCR2 signaling inhibitor in… vs Young rat aortas/VSMCs and untreated VSMCs

Design

Preclinical

Authors

GSGaia SpinettiMultiMedicaMWMingyi WangChinese PLA General HospitalRMRobert E. MonticoneNational Institutes of Health

Discussion

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Implication

Animal data implicate MCP-1/CCR2 in age-related remodeling; leaves open human therapeutic relevance.

Structured PICO

P
Population
Old (30-month) versus young (8-month) F344xBN rat aortas in vivo and isolated early-passage vascular smooth muscle cells (VSMCs)
I
Intervention
MCP-1 treatment and CCR2 signaling inhibitor (vCCI) in vitro
C
Comparator
Young rat aortas/VSMCs and untreated VSMCs
O
Outcome
MCP-1 and CCR2 mRNA and protein expression, and VSMC migration and invasion capacitysurrogate

Arterial wall and VSMC MCP-1/CCR2 increase with aging and enhance VSMC migration and invasion, suggesting a role in age-associated arterial remodeling.

Cite This Study

Spinetti et al. (2004) studied this question.

synapsesocial.com/papers/6a1a7acee916fa6dd3b8a433https://doi.org/10.1161/01.atv.0000134529.65173.08
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Also Consider

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  1. 1Inhibition of Renin-Angiotensin System Ameliorates Endothelial Dysfunction Associated With Aging in Rats2002 · 92 citations
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  4. 4Increased production of tumor necrosis factor and interleukin-6 by arterial wall of aged rats1995 · 96 citations