Thyroid hormones are positive allosteric modulators of acid-sensing ion channels ASIC1a and ASIC3

Q: What does this research mean for the field?

Thyroid hormones, particularly triiodothyronine (T3), act as positive allosteric modulators of acid-sensing ion channels ASIC1a and ASIC3 by increasing the efficacy and potency of protons. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Lu Qin; Dominik Wiemuth; Stefan Gründer

doi:10.1016/j.neuropharm.2026.111041

May 1, 2026NeuropharmacologyOpen Access

Thyroid hormones are positive allosteric modulators of acid-sensing ion channels ASIC1a and ASIC3

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Key Points

This research investigates how thyroid hormones influence the activity of acid-sensing ion channels ASIC1a and ASIC3.
Analyzed the effects of thyroid hormones on ASIC1a and ASIC3 channels.
Determined the affinity of thyroid hormones in a low micromolar range.
Evaluated the efficacy and potency of protons in relation to T3 modulation.
Triiodothyronine (T3) significantly enhances the efficacy of protons for ASIC1a.
T3 increases the potency of protons for ASIC3.
The apparent affinity of thyroid hormones for ASICs is observed in the low micromolar range.

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Implication

Shows thyroid hormones enhance acid-sensing ion channel activity, suggesting therapeutic roles.

Abstract

• Acid-sensing ion channels (ASICs) 1a and 3 are potentiated by thyroid hormones • Apparent affinity of thyroid hormones for ASICs is in the low micromolar range • Among thyroid hormones, triiodothyronine (T3) has the strongest effects • For ASIC1a, T3 increases efficacy of protons • For ASIC3, T3 increases potency of protons

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Qin et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7e6a0307b7850943112f https://doi.org/10.1016/j.neuropharm.2026.111041

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Thyroid hormones are positive allosteric modulators of acid-sensing ion channels ASIC1a and ASIC3

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Thyroid hormones are positive allosteric modulators of acid-sensing ion channels ASIC1a and ASIC3

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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