Why the study?
Data on CRT benefits in patients with both HF and AF remain limited, as patients with atrial arrhythmias were excluded from major trials.
Does CRT placement with an atrial lead improve cardiac parameters and sinus rhythm maintenance in patients with heart failure and atrial fibrillation?
Population
328 patients with AF who received CRT for HF at a single center
Comparison
CRT with an atrial lead vs without atrial lead placement
Design
Single-center retrospective analysis
Follow-up
5-year follow-up
Key result
Cardiac resynchronization therapy with an atrial lead in patients with longstanding-persistent AF was associated with stable ejection fraction and lower mitral regurgitation rates at 1 year.
Authors
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May support atrial lead use in CRT for AF; leaves open prospective confirmation of remodeling benefits.
Observational (n=328)
No
Does CRT placement with an atrial lead improve cardiac parameters and sinus rhythm maintenance in patients with heart failure and atrial fibrillation?
CRT with an atrial lead may be associated with improved myocardial function and reverse remodeling in patients with HF and AF, though larger prospective studies are needed to confirm statistical significance.
Ramadan et al. (2020) conducted an observational in Heart failure and atrial fibrillation (n=328). Cardiac resynchronization therapy (CRT) with an atrial lead vs. CRT without atrial lead placement was evaluated on Sinus rhythm conversion and maintenance, and cardiac parameters (NYHA class, MR, LVEF, left atrial diameter). Cardiac resynchronization therapy with an atrial lead in patients with longstanding-persistent AF was associated with stable ejection fraction and lower mitral regurgitation rates at 1 year.
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