Key result
Irregularly shaped lacunar infarcts were independently associated with blood pressure variability and predicted unfavorable clinical outcomes including higher mRS scores.
Why the study?
Are irregularly shaped lacunar infarctions associated with specific risk factors and worse clinical outcomes compared to regularly shaped infarctions?
Observational (n=204)
Are irregularly shaped lacunar infarctions associated with specific risk factors and worse clinical outcomes compared to regularly shaped infarctions?
Irregularly shaped lacunar infarcts are associated with blood pressure variability and predict unfavorable clinical outcomes.
May support closer BP variability monitoring in lacunar stroke; hypothesis-generating and requires prospective validation before changing practice.
OBJECTIVE: Our study focused on acute lacunar infarct shapes to explore the risk factors and clinical significance of irregularly shaped lacunar infarctions. METHODS: Based on the shape of their acute lacunar infarct, patients (n=204) were classified into the "regular" group or "irregular" group. The characteristics of the lacunar infarction were compared between the regular and irregular groups, between patients with and without neurological deterioration, and between patients with different modified Rankin scale (mRS) scores. The risk factors for irregularly shaped lacunar infarctions, neurological deterioration, and high mRS scores were identified. RESULTS: Blood pressure variability (BPV) was an independent risk factor for irregularly shaped lacunar infarction. Infarction size, prevalence of advanced leukoaraiosis, and irregularly shaped lacunar infarcts were independent risk factors for higher mRS scores. CONCLUSIONS: The irregularly shaped lacunar infarcts were correlated with BPV. Irregularly shaped lacunar infarctions and leukoaraiosis may be associated with unfavorable clinical outcomes.
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Feng et al. (2013) conducted an observational in Acute lacunar infarction (n=204). Irregularly shaped lacunar infarction vs. Regularly shaped lacunar infarction was evaluated on Risk factors for irregularly shaped lacunar infarctions, neurological deterioration, and high mRS scores. Irregularly shaped lacunar infarcts were independently associated with blood pressure variability and predicted unfavorable clinical outcomes including higher mRS scores.
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