Key result
Eight weeks of isometric handgrip training elicited a significantly greater reduction in systolic blood pressure among normotensive men with the ACE ID+DD genotype (-5.53 mmHg) compared to those with the II genotype (-1.52 mmHg).
Why the study?
The study evaluated the association between the ACE I/D gene polymorphism and isometric handgrip training on cardiovascular and muscular responses in normotensive males.
Does isometric handgrip training improve cardiovascular and muscular responses in untrained normotensive males, and is this influenced by ACE I/D gene polymorphism?
Population
30 normotensive untrained males (10 II, 10 ID, 10 DD)
Comparison
Isometric handgrip training response across ACE I/D genotypes
Follow-up
8 weeks
Authors
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ACE D allele carriers may show enhanced SBP response to isometric handgrip training; hypothesis-generating and requires randomized confirmation before clinical use.
Does isometric handgrip training improve cardiovascular and muscular responses in untrained normotensive males, and is this influenced by ACE I/D gene polymorphism?
Absolute Event Rate: -5.53% vs -1.52%
p-value: p=0.013
Isometric handgrip training effectively lowers systolic and mean arterial blood pressure in normotensive men, with a more pronounced benefit in carriers of the ACE D allele.
Yusof et al. (2018) studied Normotensive (n=30). Isometric handgrip (IHG) training vs. ACE II genotype group was evaluated on Reduction in systolic blood pressure (SBP) (p=0.013). Eight weeks of isometric handgrip training elicited a significantly greater reduction in systolic blood pressure among normotensive men with the ACE ID+DD genotype (-5.53 mmHg) compared to those with the II genotype (-1.52 mmHg).
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