Key result
The ACE DD genotype was associated with greater increases in rectus femoris size (P=0.007) and knee extensor strength (P=0.03) compared to I-allele carriers after 8 weeks of resistance training.
Why the study?
The study was conducted to explore the association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and muscle adaptations to moderate-intensity resistance training in postmenopausal women.
Does ACE I/D polymorphism affect muscle adaptations to an 8-week moderate-intensity resistance training program in healthy postmenopausal women?
Cohort (n=40)
Does ACE I/D polymorphism affect muscle adaptations to an 8-week moderate-intensity resistance training program in healthy postmenopausal women?
p-value: p=0.007 and 0.03
The ACE DD genotype is associated with greater improvements in grip strength, rectus femoris size, and knee extensor strength following 8 weeks of moderate-intensity resistance training in postmenopausal women.
May inform personalized resistance training in postmenopausal women; hypothesis-generating and requires RCT confirmation before clinical use.
OBJECTIVE: The aim of the study was to explore the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and muscle adaptations to moderate-intensity resistance training in postmenopausal women. METHODS: Forty healthy postmenopausal Chinese women (aged 53-66 years) were recruited and grouped by ACE I/D polymorphism (the homozygous deletion genotype [DD], n = 12; the I allele carriers [II/ID], n = 28). All participants performed an 8-week full-body resistance training program at moderate intensity with 15-repetition maximum. Upper- and lower-limb muscle mass, grip and back strength, anatomical cross-sectional area of the rectus femoris (ACSARF), isokinetic knee extension strength (MVCKE) and knee flexion strength were measured before and after training. RESULTS: Our results showed significant genotype × time interaction in ACSARF and MVCKE (P = 0.007 and P = 0.03, respectively) with the DD group having greater changes in corresponding parameters than the I-allele carriers (P = 0.012 and P = 0.018, respectively). Multivariate linear regression results showed that the ACE DD genotype was positively related to the grip strength adaptation (r = 0.48, P = 0.05). CONCLUSIONS: This study improves our understanding of the association between the ACE I/D polymorphism and muscular responses to moderate intensity resistance training among postmenopausal women and revealed that the DD genotype has predominant adaptations in grip strength, rectus femoris size, and knee extensor strength.
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He et al. (2019) conducted a cohort in Healthy postmenopausal women (n=40). Moderate-intensity resistance training vs. I allele carriers (II/ID) was evaluated on Anatomical cross-sectional area of the rectus femoris (ACSARF) and isokinetic knee extension strength (MVCKE) (p=0.007 and 0.03). The ACE DD genotype was associated with greater increases in rectus femoris size (P=0.007) and knee extensor strength (P=0.03) compared to I-allele carriers after 8 weeks of resistance training.
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