Why the study?
Does ACE genotype affect the muscle strength and bone mineral density response to hormone replacement therapy in postmenopausal women?
Population
Postmenopausal women
Comparison
Hormone replacement therapy (HRT) vs Comparison across ACE genotypes (II, ID, and DD)
Design
Cohort
Authors
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ACE I allele may enhance HRT muscle response; hypothesis-generating and should not yet change practice.
Does ACE genotype affect the muscle strength and bone mineral density response to hormone replacement therapy in postmenopausal women?
Low ACE activity associated with the I allele confers an improved muscle and bone mineral density response in postmenopausal women treated with hormone replacement therapy.
David R. Woods (2001) studied this question.
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