Angiotensin-Converting Enzyme Insertion/Deletion Genotype, Exercise, and Physical Decline
Key result
Among physically active older adults, those with the ACE II genotype were more likely to develop mobility limitation compared to those with ID/DD genotypes (adjusted RR 1.45; 95% CI 1.08-1.94).
Why the study?
Does the ACE genotype interact with physical activity to affect the incidence of mobility limitation in well-functioning older adults?
Population
3,075 well-functioning community-dwelling adults aged 70 through 79 years enrolled in the Health Aging and…
Comparison
Physical activity and ACE insertion/deletion… vs Inactive participants, or active participants…
Design
Cohort
Follow-up
mean 4.1 years
Authors
Discussion
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Implication
ACE II may raise mobility limitation risk in active older adults; hypothesis-generating for genotype-specific exercise effects.
Study Design
Type
Cohort (n=3,075)
Multicenter
Yes
Structured PICO
Does the ACE genotype interact with physical activity to affect the incidence of mobility limitation in well-functioning older adults?
P
Population
3,075 well-functioning community-dwelling adults aged 70 through 79 years enrolled in the Health Aging and Body Composition (Health ABC) Cohort Study.
I
Intervention
Physical activity (expending ≥1000 kcal/wk in exercise, walking, and stair climbing) and ACE insertion/deletion (I/D) genotype (specifically II genotype).
C
Comparator
Inactive participants, or active participants with ACE ID/DD genotypes.
O
Outcome
Incident mobility limitation defined as the report of difficulty walking a quarter of a mile (0.4 km) or walking up 10 steps on 2 consecutive semiannual interviews.patient reported
Main Result
Effect estimate: RR 1.45 (95% CI 1.08-1.94)
p-value: p=.002
In older adults who exercise, the ACE II genotype is associated with a higher risk of developing mobility limitation compared to the ID or DD genotypes.
Cite This Study
Stephen B. Kritchevsky (2005) conducted a cohort in Mobility limitation (n=3,075). Physical activity and ACE genotype vs. Inactive group / ID/DD genotypes was evaluated on Incident mobility limitation defined as the report of difficulty walking a quarter of a mile (0.4 km) or walking up 10 steps on 2 consecutive semiannual interviews (RR 1.45, 95% CI 1.08-1.94, p=.002). Among physically active older adults, those with the ACE II genotype were more likely to develop mobility limitation compared to those with ID/DD genotypes (adjusted RR 1.45; 95% CI 1.08-1.94).