Why the study?
Does telmisartan improve blood pressure reduction compared to valsartan in patients with hypertension?
Does telmisartan improve blood pressure reduction compared to valsartan in patients with hypertension?
Telmisartan may provide greater blood pressure reduction and improvements in metabolic and inflammatory markers compared to valsartan in the management of hypertension.
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May support telmisartan preference for BP reduction; leaves open confirmation in prospective RCTs.
The aim of this review was to compare telmisartan and valsartan in the treatment of hypertension. PubMed searches were conducted to identify randomized trials (n = 14) comparing the two agents, alone or combined with hydrochlorothiazide. With one exception, all studies with blood pressure reduction as primary endpoint showed significantly greater reductions with telmisartan than with valsartan. Other studies showed that telmisartan was associated with greater improvements in metabolic measures and inflammatory markers than valsartan. These findings suggest that pharmacologic differences between telmisartan and valsartan may translate into clinically relevant differences between the two drugs in the management of hypertension.
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Yves Lacourcière (2012) studied this question.
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