Population
HEK293 cells stably expressing HERG channels and non-transfected HEK293 cells
Comparison
HERG channel expression and exposure to H2O2… vs Non-transfected HEK293 cells
Design
Preclinical
Follow-up
10 hours (for H2O2 exposure)
Authors
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HERG may facilitate apoptosis in vitro; leaves open its role in cardiomyocyte survival or arrhythmias.
HERG channels facilitate cellular apoptosis in HEK293 cells through the activation of MAP kinases and inactivation of Akt.
Han et al. (2004) studied this question.
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