What does this research mean for the field?

Mouse liver endothelial cells constitutively coexpress thrombopoietin (TPO) and its receptor c-mpl, with TPO functioning as a growth factor for these cells. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1998BloodOpen Access

Thrombopoietin and Its Receptor, c-mpl, Are Constitutively Expressed by Mouse Liver Endothelial Cells: Evidence of Thrombopoietin as a Growth Factor for Liver Endothelial Cells

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Population

Cloned murine liver endothelial cells (LEC-1)

Design

Preclinical

Authors

JCJosé E. CardierInstituto Venezolano de Investigaciones Científicas JDJack DempseyEli Lilly (United States)

Discussion

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Implication

May indicate autocrine TPO signaling in liver endothelium; leaves open its role in human thrombopoiesis.

Structured PICO

Population

Cloned murine liver endothelial cells (LEC-1)

Intervention

In vitro treatment with tumor necrosis factor (TNF)-α, γ-interferon (INF), and thrombopoietin (TPO)

Outcome

Expression of TPO and its receptor (c-mpl) and in vitro cell growthsurrogate

This study establishes liver endothelial cells as a novel source of thrombopoietin and demonstrates that TPO acts as a growth factor for these cells in vitro.

Cite This Study

Cardier et al. (1998) studied this question.

synapsesocial.com/papers/6a1bd02f00ee29383e9cf519 https://doi.org/10.1182/blood.v91.3.923

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Thrombopoietin and Its Receptor, c-mpl, Are Constitutively Expressed by Mouse Liver Endothelial Cells: Evidence of Thrombopoietin as a Growth Factor for Liver Endothelial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thrombopoietin and Its Receptor, c-mpl, Are Constitutively Expressed by Mouse Liver Endothelial Cells: Evidence of Thrombopoietin as a Growth Factor for Liver Endothelial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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