Why the study?
Does captopril alter the metabolism or renal bioactivity of atrial natriuretic factor in normal volunteers?
Does captopril alter the metabolism or renal bioactivity of atrial natriuretic factor in normal volunteers?
ACE inhibition combined with ANF increases the activity of the hypothalamo-pituitary-adrenal axis and sympathetic nervous system without affecting ANF metabolism or renal bioactivity.
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May activate counter-regulatory hormones; hypothesis-generating for ANF-ACEI interactions in hypertension.
Richards et al. (1989) studied this question.
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