Converting enzyme inhibition prevents the effects of atrial natriuretic factor on baroreflex responses in humans.
Why the study?
Does angiotensin converting enzyme inhibition prevent the effects of atrial natriuretic factor on baroreflex responses in normal humans?
Population
13 normal volunteers
Comparison
Atrial natriuretic factor infusion during… vs Control conditions and ANF infusion before…
Follow-up
5 days
Authors
Discussion
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Member takes
Implication
ACE inhibition prevents ANF baroreflex modulation in normals; hypothesis-generating for interactions in hypertension or HF.
Structured PICO
Does angiotensin converting enzyme inhibition prevent the effects of atrial natriuretic factor on baroreflex responses in normal humans?
P
Population
13 normal volunteers
I
Intervention
Atrial natriuretic factor (ANF) infusion (50 ng/kg/min) during prolonged treatment with the converting enzyme inhibitor enalapril (20 mg p.o. for 5 days)
C
Comparator
Control conditions (placebo infusion) and ANF infusion before enalapril treatment
O
Outcome
Reflex chronotropic responses to arterial baroreceptor stimulation (phenylephrine, 25-100 micrograms i.v.) or deactivation (nitroglycerin, 25-100 micrograms i.v.)surrogate
Angiotensin converting enzyme inhibition with enalapril prevents the modulatory effects of atrial natriuretic factor on arterial baroreflex chronotropic responses in normal humans.
Cite This Study
Volpe et al. (1990) studied this question.