Why the study?
Does synthetic human atrial natriuretic factor (Wy-47,663) reduce blood pressure and alter regional blood flow in normotensive and hypertensive rats?
Population
Conscious normotensive rats, renin-dependent hypertensive rats, and rats made hypertensive by chronic…
Comparison
Infusion of increasing doses of Wy-47,663 vs Comparison between normotensive and hypertensive…
Design
Preclinical
Authors
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Supports ANF-renin-angiotensin interactions in hypertension models; leaves open human translation.
Does synthetic human atrial natriuretic factor (Wy-47,663) reduce blood pressure and alter regional blood flow in normotensive and hypertensive rats?
Synthetic atrial natriuretic factor produces greater depressor responses in renin-dependent and angiotensin II-infused hypertensive rats compared to normotensive rats, highlighting its interaction with the renin-angiotensin system.
Lappe et al. (1987) studied this question.
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