November 24, 2004Clinical Science
Cardiovascular risk factors and endothelial dysfunction
Why the study?
Does endothelial dysfunction correlate with calculated cardiovascular risk scores in patients with and without established CHD?
Population
246 patients (187 male), including 44 (22%) with established CHD.
Comparison
Measurement of endothelial function via ACh/NP… vs Calculated cardiovascular risk from Framingham…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Endothelial dysfunction markers may refine risk models in men; leaves open prospective validation for incremental value over Framingham.
Structured PICO
Does endothelial dysfunction correlate with calculated cardiovascular risk scores in patients with and without established CHD?
P
Population
246 patients (187 male), including 44 (22%) with established CHD.
I
Intervention
Measurement of endothelial function via ACh/NP (acetylcholine/sodium nitroprusside response) ratio on brachial plethysmography
C
Comparator
Calculated cardiovascular risk from Framingham, PROCAM, and MRFIT algorithms
O
Outcome
Relationship between the degree of endothelial dysfunction and calculated cardiovascular risksurrogate
Endothelial dysfunction correlates better with the PROCAM risk algorithm than Framingham, reflecting the strong contribution of male sex, LDL-cholesterol, and triglycerides to endothelial dysfunction.
Cite This Study
Wierzbicki et al. (2004) studied this question.