Advances in the diagnosis and treatment of hypertension may improve clinical outcomes for patients with diastolic dysfunction.
May support hypertension optimization in diastolic dysfunction; leaves open dedicated RCTs to confirm outcome gains.
Diastolic dysfunction is a poorly understood pathophysiological entity; its importance is magnified by the increasing prevalence of diastolic heart failure. Forty-six million people in the US are experiencing heart failure and 550000 new cases are diagnosed annually. A large percentage of these patients with heart failure have a normal or nearly normal left-ventricular ejection fraction. Isolated diastolic dysfunction may be associated with an increased mortality. One of the major causes of diastolic dysfunction is hypertension. Advances in diagnosis and treatment strategies may improve the clinical outcome for patients with diastolic dysfunction.
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Krishnan et al. (2003) studied this question.
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