What question did this study set out to answer?

The study aims to measure pulsatile pressures in microvessels of the myocardial epimyocardium of rats and cats.

November 1, 1981Circulation ResearchOpen Access

Pressure measurements in the terminal vascular bed of the epimyocardium of rats and cats.

Q: What does this research mean for the field?

The contractile state of the myocardium and left ventricular afterload are the major determinants of systolic coronary venular pressure. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Population

9 cats and 25 rats

Comparison

Micropuncture and micropipet servo-nulling… vs Baseline/control measurements

Design

Preclinical

Authors

HTHarald TillmannsUniversity of Southern California MSM. SteinhausenHeidelberg University HLH. LeinbergerHeidelberg University

Discussion

Member takes

Implication

Requires accounting for contractility in coronary pressure studies; leaves open human translation of these animal findings.

Key Points

The study aims to measure pulsatile pressures in microvessels of the myocardial epimyocardium of rats and cats.
Developed a resistance servo-nulling technique for pulsatile pressure measurement in microvessels of the heart.
Used in vivo microscopy and a television camera system in 9 cats and 25 rats for observation.
Determined intrahuninal pressures via micropuncture and micropipet servo-nulling.
Smaller arterioles (<100μm) showed a pressure drop between the ascending aorta and pressure recording site.
Systolic coronary venular pressure was slightly increased by dipyridamole (controls 25.3 mm Hg, dipyridamole 27.6 mm Hg).
Positive inotropic interventions with dobutamine and norepinephrine caused a substantial increase in systolic coronary venular pressure.

Structured PICO

Population

9 cats and 25 rats

Intervention

Micropuncture and micropipet servo-nulling system for pressure measurement, with pharmacological interventions (dipyridamole 0.5 mg/kg iv, dobutamine 6 μg/kg per min iv, norepinephrine)

Comparator

Baseline/control measurements

Outcome

Intraluminal pressures in the microvascular bed of the ventricular epimyocardiumsurrogate

The contractile state of the myocardium and left ventricular afterload are the major determinants of systolic coronary venular pressure in the mammalian heart.

Cite This Study

Tillmanns et al. (1981) studied this question.

synapsesocial.com/papers/6a1be446c97d63156a5f1190 https://doi.org/10.1161/01.res.49.5.1202

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Pressure measurements in the terminal vascular bed of the epimyocardium of rats and cats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Pressure measurements in the terminal vascular bed of the epimyocardium of rats and cats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider