Key result
Transvalvular aortic micromanometers continuously reproduce LV pressure without altering cardiac performance in isolated rat hearts.
Population
Isolated buffer-perfused working rat heart
Comparison
Transvalvular placement of a micromanometer… vs Pullback from the ventricle to the aorta
Design
Preclinical
Authors
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May enable refined hemodynamic studies in isolated rat hearts; leaves open translation to in vivo or clinical models.
Transvalvular placement of a micromanometer is a stable and non-traumatic method for continuous left ventricular pressure measurement in isolated working rat hearts.
Skeehan et al. (1992) studied Isolated working rat heart. Transvalvular placement of a micromanometer through the aorta was evaluated on Continuous, high-fidelity reproduction of LV pressure and cardiac performance alteration. Transvalvular placement of a micromanometer through the aorta provided continuous, high-fidelity reproduction of LV pressure in isolated rat hearts without significantly altering cardiac performance.
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