What does this research mean for the field?

Cells in the cochlear spiral modiolar artery exist in two distinct, exchangeable resting potential states (high and low) that are regulated primarily by all-or-none-like conductance changes of the inward-rectifier potassium channel. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 15, 2001The Journal of PhysiologyOpen Access

Two resting potential levels regulated by the inward-rectifier potassium channel in the guinea-pig spiral modiolar artery

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Population

771 cells from the guinea-pig spiral modiolar artery (SMA) in vitro

Design

Preclinical

Authors

ZJZhi‐Gen JiangOregon Health & Science University JSJun‐Qiang SiShihezi University MLMichael LasarevUniversity of Wisconsin–Madison

Discussion

Member takes

Implication

Hypothesis-generating for cochlear vascular tone; leaves open translation to human inner ear disorders.

Structured PICO

Population

771 cells from the guinea-pig spiral modiolar artery (SMA) in vitro

Intervention

Application of pharmacological agents including acetylcholine, high extracellular potassium, barium, 18 beta-glycyrrhetinic acid, nitric oxide, pinacidil, and ouabain

Outcome

Resting membrane potential and its response to pharmacological agentssurrogate

Smooth muscle and endothelial cells in the guinea-pig spiral modiolar artery exist in two distinct, exchangeable resting potential states regulated by inward-rectifier potassium channels.

Cite This Study

Jiang et al. (2001) studied this question.

synapsesocial.com/papers/6a1be90cea84844e355f2ad2 https://doi.org/10.1111/j.1469-7793.2001.00829.x

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Two resting potential levels regulated by the inward-rectifier potassium channel in the guinea-pig spiral modiolar artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Two resting potential levels regulated by the inward-rectifier potassium channel in the guinea-pig spiral modiolar artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider