What does this research mean for the field?

Increased levels of muscle-specific microRNAs (miR-1 and miR-133) in heart failure promote arrhythmogenesis by suppressing PP2A phosphatase activity, which leads to hyperphosphorylation of the RyR2 calcium channel. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 6, 2011PLoS ONEOpen Access

MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex

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Population

Isolated hearts from canines with chronic heart failure exhibiting increased left ventricular dimensions and…

Comparison

Pharmacological inhibition of phosphatase… vs Control myocytes

Design

Preclinical

Authors

ABAndriy E. BelevychThe Ohio State University Wexner Medical Center SSSarah E. SansomRush University Medical Center RTRadmila TerentyevaThe Ohio State University Wexner Medical Center

Discussion

Member takes

Implication

miR-1/133 modulation merits investigation as anti-arrhythmic target in HF; hypothesis-generating in animal models only.

Structured PICO

Population

Isolated hearts from canines with chronic heart failure (HF) exhibiting increased left ventricular (LV) dimensions and decreased LV contractility, and control myocytes.

Intervention

Pharmacological inhibition of phosphatase activity and CaMKII inhibitory peptide

Comparator

Control myocytes

Outcome

Levels of miR-1 and miR-133, expression of PP2A subunits, RyR2 phosphorylation, and frequency of diastolic Ca(2+) waves and afterdepolarizationssurrogate

Increased levels of miR-1 and miR-133 in heart failure contribute to arrhythmogenesis by depressing PP2A phosphatase activity, leading to RyR2 hyperphosphorylation and abnormal calcium cycling.

Cite This Study

Belevych et al. (2011) studied this question.

synapsesocial.com/papers/6a1bee67ea84844e355f2fe7 https://doi.org/10.1371/journal.pone.0028324

Topics

Heart failure HFrEF treatment

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MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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