What question did this study set out to answer?

To review the biological role of cyclic AMP as a secondary messenger mediating metabolic and physiological hormone actions, including cardiac inotropic responses.

February 1, 1968CirculationOpen Access

Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)

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Authors

ESEarl W. SutherlandSwansea Bay University Health Board GRG. Alan RobisonHarvard University RBR.W. ButcherBoston University

Discussion

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Overview

Scientific review reveals that cyclic AMP mediates metabolic actions and inotropic responses, highlighting broad therapeutic potential for clinical research.

Key Points

To review the biological role of cyclic AMP as a secondary messenger mediating metabolic and physiological hormone actions, including cardiac inotropic responses.
Synthesized biochemical and physiological evidence on cyclic AMP mechanisms in hormonal cellular signaling.
Evaluated functional and mechanical evidence regarding catecholamine-induced positive inotropic responses in cardiac tissue.
Cyclic AMP functions as a general intracellular second messenger mediating diverse metabolic and functional hormone responses.
Experimental evidence supports the role of cyclic AMP in driving the positive inotropic response to catecholamines.
Translational relevance remains largely untapped, providing a strong rationale for targeted clinical investigation.

Cite This Study

Sutherland et al. (1968) studied this question.

synapsesocial.com/papers/6a1beef61567d2fc4d5f47ce https://doi.org/10.1161/01.cir.37.2.279

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February 1, 1968CirculationOpen Access

Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)

View Full Paper

Ask AI

Bookmark

Authors

ESEarl W. SutherlandSwansea Bay University Health Board GRG. Alan RobisonHarvard University RBR.W. ButcherBoston University

Discussion

Member takes

Overview

Scientific review reveals that cyclic AMP mediates metabolic actions and inotropic responses, highlighting broad therapeutic potential for clinical research.

Key Points

To review the biological role of cyclic AMP as a secondary messenger mediating metabolic and physiological hormone actions, including cardiac inotropic responses.
Synthesized biochemical and physiological evidence on cyclic AMP mechanisms in hormonal cellular signaling.
Evaluated functional and mechanical evidence regarding catecholamine-induced positive inotropic responses in cardiac tissue.
Cyclic AMP functions as a general intracellular second messenger mediating diverse metabolic and functional hormone responses.
Experimental evidence supports the role of cyclic AMP in driving the positive inotropic response to catecholamines.
Translational relevance remains largely untapped, providing a strong rationale for targeted clinical investigation.

Cite This Study

Sutherland et al. (1968) studied this question.

synapsesocial.com/papers/6a1beef61567d2fc4d5f47ce https://doi.org/10.1161/01.cir.37.2.279

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