What does this research mean for the field?

Adding captopril to a diuretic-based regimen safely and effectively improves functional capacity and reduces symptoms in patients with mild to moderate congestive heart failure in a primary care setting, regardless of age, disease duration, or concurrent digoxin use. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the effect of captopril added to existing heart failure treatments in improving patient outcomes.

August 1, 1991Clinical Cardiology

A large‐scale trial of captopril for mild to moderate heart failure in the primary care setting

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Why the study?

Does adding captopril to standard therapy improve functional capacity and symptoms in patients with mild to moderate congestive heart failure?

Population

6,669 patients with mild to moderate congestive heart failure (CHF) evaluated by 2,218 primary care physicians

Design

Cohort

Follow-up

8 weeks

Authors

RDRobert DiBiancoAdventist HealthCare

Discussion

Member takes

Implication

May support captopril addition for mild-moderate HF in primary care; leaves open need for randomized confirmation.

Key Points

To assess the effect of captopril added to existing heart failure treatments in improving patient outcomes.
Large-scale, prospective, office-based study over 8 weeks involving 6669 patients.
Evaluated improvements in functional ability and symptoms using modified NYHA classification.
Included assessments of daily activities such as walking distance and climbing stairs.
63.8% of patients showed improvements in functional ability, with 19% improving two or more NYHA classes.
86% reported reductions in CHF symptoms, with varying degrees of improvement in dyspnea and fatigue.
78.5% increased walking distance, while 72.3% improved stair climbing capacity.

Structured PICO

Does adding captopril to standard therapy improve functional capacity and symptoms in patients with mild to moderate congestive heart failure?

Population

6,669 patients with mild to moderate congestive heart failure (CHF) evaluated by 2,218 primary care physicians

Intervention

Captopril added to a therapeutic regimen of diuretic and digoxin or diuretic alone

Outcome

Efficacy parameters including changes in a modified New York Heart Association (NYHA) functional classification, symptomatology, and daily activity levelspatient reported

Adding captopril to diuretic therapy (with or without digoxin) safely improves functional capacity and symptoms in patients with mild to moderate heart failure in a primary care setting.

Cite This Study

Robert DiBianco (1991) studied this question.

synapsesocial.com/papers/6a1befec26cb5670aa9d22ac https://doi.org/10.1002/clc.4960140810

Topics

Heart failure HFrEF treatment Heart failure hospitalization HFpEF management

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A large‐scale trial of captopril for mild to moderate heart failure in the primary care setting

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

A large‐scale trial of captopril for mild to moderate heart failure in the primary care setting

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider