What does this research mean for the field?

In patients with advanced systolic heart failure, simultaneous biventricular, sequential biventricular, and left ventricular pacing all significantly improve systolic function and reduce ventricular volumes, with simultaneous biventricular pacing providing the greatest reduction in left ventricular end-systolic dimension. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 10, 2007Circulation

Reduced Ventricular Volumes and Improved Systolic Function With Cardiac Resynchronization Therapy

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Why the study?

Does simultaneous or sequential biventricular pacing improve left ventricular volumes and systolic function compared to left ventricular pacing in patients with advanced systolic heart failure?

Population

306 patients with New York Heart Association class III or IV heart failure, a left ventricular ejection…

Comparison

Simultaneous biventricular pacing or sequential… vs Left ventricular (LV) pacing

Design

RCT, Randomized to simultaneous BiV, sequential BiV, or LV pacing

Follow-up

6 months

Authors

RRRajni K. RaoKeck Hospital of USC UKUday KumarStempeutics (India)JSJill SchaferUniversity Children's Hospital Tübingen

Discussion

Member takes

Implication

Simultaneous BiV pacing yields greater LV reverse remodeling than LV pacing in advanced systolic HF; extends CRT optimization comparisons.

Structured PICO

Does simultaneous or sequential biventricular pacing improve left ventricular volumes and systolic function compared to left ventricular pacing in patients with advanced systolic heart failure?

Population

306 patients with New York Heart Association class III or IV heart failure, a left ventricular ejection fraction ≤ 35%, and a QRS duration ≥ 150 ms

Intervention

Simultaneous biventricular (BiV) pacing or sequential BiV pacing

Comparator

Left ventricular (LV) pacing

Outcome

Left ventricular volumes (end-systolic and end-diastolic dimensions) and systolic and diastolic function (stroke volume, LV ejection fraction) assessed with echocardiography at 3 months and 6 monthssurrogate

Simultaneous biventricular pacing provides a greater reduction in left ventricular end-systolic dimension compared to left ventricular pacing, though improvements in ejection fraction and stroke volume are similar across pacing modes.

Cite This Study

Rao et al. (2007) studied this question.

synapsesocial.com/papers/6a1bf49cea84844e355f39bb https://doi.org/10.1161/circulationaha.106.634444

Topics

HFrEF treatment Heart failure Mitral valve intervention Tricuspid regurgitation Cardiomyopathy

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Implication

Simultaneous BiV pacing yields greater LV reverse remodeling than LV pacing in advanced systolic HF; extends CRT optimization comparisons.

Reduced Ventricular Volumes and Improved Systolic Function With Cardiac Resynchronization Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Reduced Ventricular Volumes and Improved Systolic Function With Cardiac Resynchronization Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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