Key result
Diabetes increased the 10-year risk for CHD (HR 1.99 for men, 2.93 for women), but only diabetic subjects with multiple risk factors had a CHD incidence (>40%) equivalent to patients with prior CHD.
Why the study?
Is diabetes a coronary heart disease risk equivalent regardless of concomitant risk factors?
Population
4,549 men and women, with and without baseline CHD or CVD, in a population with a high prevalence of diabetes
Comparison
Presence of diabetes (exposure) vs Nondiabetic individuals with and without…
Design
Cohort
Follow-up
10 years
Authors
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Diabetes is not a universal CHD risk equivalent; challenges prior assumptions and leaves open refined stratification in diabetes.
Cohort (n=4,549)
Is diabetes a coronary heart disease risk equivalent regardless of concomitant risk factors?
Effect estimate: HR 1.99 (men) and 2.93 (women)
Diabetes is not universally a CHD risk equivalent; the 10-year CHD risk in diabetic patients depends heavily on the presence of concomitant risk factors.
Howard et al. (2006) conducted a cohort in Diabetes (n=4,549). Diabetes vs. Nondiabetic individuals (with and without previous CHD) was evaluated on 10-year cumulative incidence of fatal and nonfatal CHD and CVD (HR 1.99 (men) and 2.93 (women)). Diabetes increased the 10-year risk for CHD (HR 1.99 for men, 2.93 for women), but only diabetic subjects with multiple risk factors had a CHD incidence (>40%) equivalent to patients with prior CHD.
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