Key result
PREFERS Hypertension tracks the transition from uncomplicated hypertension to HFpEF using imaging and biomarkers.
Why the study?
Hypertension carries a significant risk for HFpEF without evidence-based medical treatment, and the underlying mechanisms behind the transition from uncomplicated hypertension to hypertensive heart disease and HFpEF remain unclear.
Population
250 patients with primary hypertension and 60 healthy controls
Comparison
Patients with primary hypertension vs healthy controls
Design
Prospective cohort study
Follow-up
6 years
Authors
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May identify early HFpEF predictors in hypertension; leaves open preventive strategies pending validation.
Cohort (n=310)
No
The PREFERS Hypertension study is a prospective cohort designed to identify early imaging and biomarker changes that predict the transition from uncomplicated hypertension to heart failure with preserved ejection fraction.
Ekström et al. (2020) conducted a cohort in Primary hypertension (n=310). Primary hypertension vs. Healthy controls was evaluated on Mean change of E/e' of ≥2 or mean change of LA volume index of ≥4 mL/m2 after 1 year. The PREFERS Hypertension study is a prospective cohort study designed to investigate the transition from uncomplicated hypertension to hypertensive heart disease and HFpEF using cardiac imaging and biomarkers.
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