What question did this study set out to answer?

To compare the blood pressure-lowering efficacy, pulse rate effects, and side-effect profiles of four beta-adrenergic blocking drugs in hypertensive patients.

May 1, 1974Postgraduate Medical JournalOpen Access

A comparison of beta adrenergic blocking drugs in the treatment of hypertension

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Why the study?

Do different beta-blockers (propranolol, prindolol, alprenolol, timolol) differ in their antihypertensive properties and side effect profiles in patients with hypertension?

Population

Patients with hypertension

Comparison

Beta adrenergic blocking drugs vs Active comparators

Design

RCT, Double blind

Follow-up

long-term

Authors

TMT. O. MorganThe University of Melbourne SAS. N. AnavekarThe University of Melbourne JSJ. SabtoHôpital Necker-Enfants Malades

Discussion

Member takes

Implication

Beta-blockers may be chosen by heart-rate profile without sacrificing BP control; confirms class-wide antihypertensive equivalence with differentiated chronotropic effects.

Key Points

To compare the blood pressure-lowering efficacy, pulse rate effects, and side-effect profiles of four beta-adrenergic blocking drugs in hypertensive patients.
Evaluated long-term antihypertensive therapy in patients with hypertension.
Conducted a double-blind trial directly comparing propranolol, prindolol, alprenolol, and MK 950 (timolol).
Beta-adrenergic blocking agents served as an extremely satisfactory treatment in 40% of patients, with the four drugs producing falls in blood pressure that were not significantly different.
Propranolol and timolol induced a greater reduction in pulse rate and were associated with bronchospasm, whereas prindolol and alprenolol caused more frequent and severe dream pattern disturbances.

Structured PICO

Do different beta-blockers (propranolol, prindolol, alprenolol, timolol) differ in their antihypertensive properties and side effect profiles in patients with hypertension?

Population

Patients with hypertension

Intervention

Beta adrenergic blocking drugs (propranolol, prindolol, alprenolol, and timolol)

Comparator

Active comparators (the four beta-blockers compared against each other)

Outcome

Fall in blood pressuresurrogate

Various beta-blockers provide similar antihypertensive efficacy but exhibit distinct side effect profiles regarding heart rate reduction, bronchospasm, and sleep disturbances.

Cite This Study

Morgan et al. (1974) studied this question.

synapsesocial.com/papers/6a1c08dfd54006be995f704c https://doi.org/10.1136/pgmj.50.583.253

Topics

Hypertension management

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Implication

Beta-blockers may be chosen by heart-rate profile without sacrificing BP control; confirms class-wide antihypertensive equivalence with differentiated chronotropic effects.

A comparison of beta adrenergic blocking drugs in the treatment of hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

A comparison of beta adrenergic blocking drugs in the treatment of hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider