Key result
Alprenolol and propranolol demonstrated an almost identical blood pressure-reducing effect in subjects with mild hypertension, although propranolol reduced heart rate significantly more.
Why the study?
Does alprenolol have a similar blood pressure-reducing effect compared to propranolol in subjects with mild hypertension?
Population
26 subjects with mild hypertension
Comparison
Alprenolol in equipotent β-blocking doses vs Propranolol in equipotent β-blocking doses
Design
Other, double-blind
Authors
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Alprenolol may match propranolol for BP reduction in mild hypertension with less HR slowing; leaves open comparative utility pending higher-level trials.
RCT (n=26)
Double-blind
Does alprenolol have a similar blood pressure-reducing effect compared to propranolol in subjects with mild hypertension?
Alprenolol and propranolol provide similar blood pressure reduction in mild hypertension, despite differing effects on heart rate.
Calle Bengtsson (1972) conducted an RCT in mild hypertension (n=26). Alprenolol vs. Propranolol was evaluated on BP-reducing effect. Alprenolol and propranolol demonstrated an almost identical blood pressure-reducing effect in subjects with mild hypertension, although propranolol reduced heart rate significantly more.
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