Why the study?
Does propranolol reduce arterial pressure more effectively than alprenolol in hypertensive patients?
Does propranolol reduce arterial pressure more effectively than alprenolol in hypertensive patients?
Propranolol is more effective than alprenolol in reducing arterial pressure and heart rate in hypertensive patients.
Answers are grounded in this paper and cite their sources.
May favor propranolol over alprenolol for BP control; leaves open confirmation in randomized trials.
AbstractIn an individually titrated dose cross‐over trial of propranolol and alprenolol in 18 hypertensive patients both drugs were useful as antihypertensive agents although propranolol in the used dosages was found to be more effective and caused a significantly greater reduction of arterial pressure both in the supine position (systolicp<0.05, diastolicp<0.01) and in the erect position (diastolicp<0.0025). Propranolol reduced the heart rate significantly more than alprenolol.
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Berglund et al. (1973) studied this question.
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