Why the study?
Does the combination of alprenolol and hydralazine reduce blood pressure more than alprenolol and placebo in patients with moderate essential hypertension?
Does the combination of alprenolol and hydralazine reduce blood pressure more than alprenolol and placebo in patients with moderate essential hypertension?
The combination of alprenolol and hydralazine provides a significantly greater reduction in blood pressure compared to alprenolol alone in patients with moderate essential hypertension.
Supports alprenolol-hydralazine combination for greater BP reduction in moderate hypertension; confirms additive effects of beta-blocker plus vasodilator in RCT.
Seventeen patients with moderate essential hypertension were included in a double‐blind crossover study, comparing the antihypertensive effect of a combination of alprenolol and hydralazine to that of alprenolol and placebo. Both treatments resulted in a significant decrease in blood pressure compared to initial values. The effects of the combination of alprenolol and hydralazine were significantly more pronounced than those of alprenolol alone. After the crossover study the patients were followed up for 12 months and despite dose reductions of the two drugs in several patients the blood pressure remained virtually unchanged, compared to the values of the crossover study. It is concluded that the combination of alprenolol and hydralazine is a good alternative to other drug treatment in hypertension.
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J. F. Pape (1974) studied this question.