Key result
Alprenolol induced a significant decrease in systolic and diastolic blood pressure and plasma renin activity in patients with essential hypertension on chlorthalidone treatment.
Why the study?
Does alprenolol reduce blood pressure and plasma renin activity in patients with essential hypertension on chlorthalidone treatment?
Population
17 patients with essential hypertension on chlorthalidone treatment
Design
RCT, double-blind
Authors
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Alprenolol addition to chlorthalidone reduces BP and renin; confirms additive beta-blocker benefit in essential hypertension.
RCT (n=17)
Double-blind
Crossover
Does alprenolol reduce blood pressure and plasma renin activity in patients with essential hypertension on chlorthalidone treatment?
Alprenolol significantly decreases blood pressure and plasma renin activity in hypertensive patients already receiving chlorthalidone.
Castenfors et al. (1973) conducted an RCT in Essential hypertension (n=17). Alprenolol vs. Placebo/Baseline was evaluated on Blood pressure, plasma renin activity, and blood volume. Alprenolol induced a significant decrease in systolic and diastolic blood pressure and plasma renin activity in patients with essential hypertension on chlorthalidone treatment.
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