Thrombin Inhibitors and Cardiopulmonary Bypass

Q: What is the clinical evidence from this study?

Study design: Review. Population: Cardiac surgery requiring cardiopulmonary bypass. Intervention: Direct thrombin inhibitors (e.g., bivalirudin) vs. Unfractionated heparin and protamine.

Q: What does this research mean for the field?

Direct thrombin inhibitors such as bivalirudin provide a viable alternative to heparin for anticoagulation during cardiopulmonary bypass, particularly in patients with heparin-induced thrombocytopenia. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Alan Merry

doi:10.1051/ject/200638052

March 1, 2006Journal of ExtraCorporeal TechnologyOpen Access

Thrombin Inhibitors and Cardiopulmonary Bypass

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Why the study?

Does targeted delivery of AdS16EPLN via an extracorporeal circuit improve contractile function and prevent ventricular remodeling in an ovine pacing-induced heart failure model?

Structured PICO

Does targeted delivery of AdS16EPLN via an extracorporeal circuit improve contractile function and prevent ventricular remodeling in an ovine pacing-induced heart failure model?

P

Population

Ovine pacing-induced heart failure model (n=15)

I

Intervention

Adenovirus encoding a pseudophosphorylated mutant PLN (AdS16EPLN, 3.5x10^12 vp) delivered via a low volume extracorporeal circuit (V-Focus system) recirculated for 10 minutes

C

Comparator

AdLacZ (4.7x10^12 vp) delivered via the same extracorporeal circuit

O

Outcome

Contractile function and ventricular remodelingsurrogate

Limitations

Experience with bivalirudin on cardiopulmonary bypass is still limited.
The relationship between dose, effect, and activated clotting time during cardiopulmonary bypass is not entirely clear.
No current studies have graft patency as a primary endpoint.

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Implication

Targeted delivery of AdS16EPLN via a novel extracorporeal circuit improves contractile function and prevents ventricular remodeling in a sheep model of pacing-induced heart failure.

Abstract

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Discussion

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Cite This Study

Alan Merry (2006) conducted a review in Cardiac surgery requiring cardiopulmonary bypass. Direct thrombin inhibitors (e.g., bivalirudin) vs. Unfractionated heparin and protamine was evaluated.

synapsesocial.com/papers/6a1c14e74cc49ccc94a90886 https://doi.org/10.1051/ject/200638052

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Thrombin Inhibitors and Cardiopulmonary Bypass

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Thrombin Inhibitors and Cardiopulmonary Bypass

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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