Key result
In patients with prior myocardial infarction and left ventricular ejection fraction ≤40%, an ejection fraction ≤30% significantly increased the risk of cardiac death (HR 5.6) compared to an ejection fraction >30%.
Why the study?
The study was conducted to assess the incidence of sudden cardiac death in post-myocardial infarction patients and evaluate the predictive value of various risk markers for cardiac mortality and sudden cardiac death.
Comparison
Predictive value of various risk markers (left ventricular function, Holter arrhythmias, MTWA)
Design
Prospective cohort study
Follow-up
Mean 22.3 ± 6.6 months
Authors
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LVEF ≤30% flags higher-risk post-MI patients; leaves open whether ICDs improve survival in this Indian cohort.
Cohort (n=58)
No
Effect estimate: HR 5.6 (95% CI 1.39-23)
Absolute Event Rate: 30% vs 5.3%
p-value: p=<0.01
In Indian survivors of myocardial infarction with reduced ejection fraction, LVEF ≤30% and non-sustained ventricular tachycardia are strong independent predictors of cardiac death, supporting the use of ICDs for primary prevention in this high-risk group.
Selvaraj et al. (2020) conducted a cohort in Prior myocardial infarction with left ventricular ejection fraction ≤40% (n=58). Left ventricular ejection fraction ≤30% vs. Left ventricular ejection fraction >30% was evaluated on Composite of cardiac death and resuscitated cardiac arrest (HR 5.6, 95% CI 1.39-23, p=<0.01). In patients with prior myocardial infarction and left ventricular ejection fraction ≤40%, an ejection fraction ≤30% significantly increased the risk of cardiac death (HR 5.6) compared to an ejection fraction >30%.
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