Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood
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Key result
The heritability of carotid-distal pulse wave velocity decreased from 62% in youth to 35% in young adulthood, with novel genetic influences accounting for 19% of the variance at the second visit.
Why the study?
The relative contributions of genetic and environmental factors, and potential ethnic differences, to the stability of carotid-distal PWV from youth to young adulthood were unknown.
Population
497 European American and African American twins
Design
Twin modelling study
Follow-up
Average interval time of 3 years
Authors
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Implication
Dynamic heritability of arterial stiffness may refine age-specific risk models; leaves open identification of emergent variants for future studies.
Study Design
Type
Cohort (n=497)
Structured PICO
P
Population
497 overtly healthy European American (EA) and African American (AA) twins (289 EA, 208 AA) from the Georgia Cardiovascular Twin Study, mean age approximately 17 years at baseline.
O
Outcome
Relative contributions of genetic and environmental factors to the stability of carotid-distal pulse wave velocity (PWV) from youth to young adulthood (heritability of PWV).surrogate
Main Result
Absolute Event Rate: 0.35% vs 0.62%
p-value: p=<0.01
The heritability of pulse wave velocity decreases from youth to young adulthood, with novel genetic effects emerging over time, suggesting age-specific genetic influences on arterial stiffness.
Limitations
- The generalizability of the results to other adult or elderly populations remains to be determined.
- The sample size may not have enough power to detect ethnic or gender differences in the relative contributions of genetic and environmental factors to the variations of PWV.
- Generalizability of the results to other adult or elderly populations remains to be determined.
- Sample size may not have enough power to detect ethnic or gender differences in the relative contributions of genetic and environmental factors to the variations of PWV.
Cite This Study
Huang et al. (2021) conducted a cohort in Healthy (n=497). The heritability of carotid-distal pulse wave velocity decreased from 62% in youth to 35% in young adulthood, with novel genetic influences accounting for 19% of the variance at the second visit.
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