Why the study?
Does renal hypertension increase the rate of cell replication in the aortic endothelium of rats?
Does renal hypertension increase the rate of cell replication in the aortic endothelium of rats?
Renal hypertension significantly increases the rate of aortic endothelial cell replication in rats, likely as a proliferative response to vessel dilation.
No clinical implications yet; leaves open endothelial replication as a driver of hypertensive vascular remodeling in humans.
The daily rate of cell replication in the aortic endothelium of the normal rat falls from a maximum of 13% at birth to 0.1-0.3% at age 5-6 months. This residual rate of replication largely represents the turnover rate of the endothelium in normal animals. After renal hypertension of 2-3 weeks duration, however, the rate of replication rises 10-fold to an average value of 1.6%. This increase may represent an increase in turnover; however, it probably represent, at least in part, a proliferative response to cover the expanded luminal surface of the dilated vessel.
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Schwartz et al. (1977) studied this question.
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