Key result
Chronic nitroglycerin treatment impaired functional sympatholysis in healthy rats and humans, enhancing exercise-induced decreases in muscle oxygenation in humans (-9% vs -3%; P<0.05).
Why the study?
Does chronic nitroglycerin treatment impair functional sympatholysis in healthy rats and humans?
Population
Healthy rats and healthy humans
Comparison
Chronic treatment with nitroglycerin to induce… vs Vehicle-treated rats; humans before NTG treatment
Design
Preclinical
Authors
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May warrant caution during exercise with chronic nitroglycerin; leaves open relevance in cardiovascular disease.
Does chronic nitroglycerin treatment impair functional sympatholysis in healthy rats and humans?
Absolute Event Rate: -9% vs -3%
p-value: p=<0.05
Chronic nitroglycerin treatment induces nitrate tolerance and oxidative stress, which impairs functional sympatholysis in both healthy rats and humans.
Fadel et al. (2011) studied Healthy (nitrate tolerance induced). Nitroglycerin (NTG) vs. Vehicle (rats) / Before NTG (humans) was evaluated on LBNP-induced decreases in muscle oxygenation during handgrip exercise in humans (p=<0.05). Chronic nitroglycerin treatment impaired functional sympatholysis in healthy rats and humans, enhancing exercise-induced decreases in muscle oxygenation in humans (-9% vs -3%; P<0.05).
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